Résumé
Availability of well-tolerated novel agents that can slow or stop disease progression and improve quality of life remain an unmet medical need in IPF management. GB0139, a novel inhaled galectin-3 inhibitor, has shown good tolerability and antifibrotic potential via changes in biomarkers associated with IPF progression in an animal model (Delaine, T. et al. Chembiochem 2016;17:1759-70) and a Phase I study (Hirani, N. et al. Eur Respir J 2021;57(5):2002559) in healthy participants and IPF patients. We report the design of a Phase IIb study of GB0139 in IPF. This randomised, double-blind, placebo-controlled, parallel-group, multicentre study (NCT03832946) was initiated in April 2019. The primary endpoint is rate of decline in forced vital capacity (FVC) over 52 weeks. Key secondary endpoints are proportion of participants with an absolute decline from baseline in FVC % predicted of <=10%, change from baseline in St. George's Respiratory Questionnaire total score, time to first respiratory-related hospitalisation, and time to death (all-causes). Systemic GB0139 pharmacokinetics are included as an exploratory endpoint. Despite the COVID-19 pandemic, study recruitment has continued in ~100 centres across 15 countries, with over 400 participants randomised as of February 2022. Initially, participants treated with or without standard of care (SOC) were included. Following a protocol amendment in 2021, the current target is to randomise 141 participants who are not treated with SOC, with study completion in mid-2023.
Résumé
Background: College students have taken to massive multiplayer online games (MMOG) for entertainment during this COVID pandemic. However, it could jeopardize their mental health risk if unregulated. Aim: This study aims to examine the relationship between gaming hours and key components of mental health viz self-compassion and online/offline integration, along with the role of time as a moderator in the relationship. Methods: A sample of 515 students who play MMOGs completed a set of standardized questionnaires. Descriptive, inferential analyses and moderated multiple regression were performed to study these relationships. Result: The results demonstrated a positive correlation between low game time, self-compassion and integration of online/offline life. Gamers with high self-compassion devoted lesser number of hours and tended to be well integrated in terms of their identity, social relations and functions in both online and offline lives as compared to gamers with low self-compassion who played for extensive hours. Conclusion: Limiting the game time by a couple of hours and incorporation of self-compassion intervention can evade the risks of gaming addiction and other related psychological disorders © This work is licensed under a Creative Commons Attribution-No Derivative Works 2.5 India License
Résumé
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key role in the lung injury characteristic of non-COVID-19 ARDS and there is also accumulating evidence of neutrophil mediated lung injury in patients who succumb to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: We undertook a functional proteomic and metabolomic survey of circulating neutrophil populations, comparing patients with COVID-19 ARDS and non-COVID-19 ARDS to understand the molecular basis of neutrophil dysregulation.